Pivikto 150MG Tablet (28’s)
Pivikto 150MG Tablet, containing Alpelisib as its active ingredient, is a targeted therapy primarily used in the treatment of certain types of breast cancer, particularly hormone receptor-positive, HER2-negative breast cancer. This medication is designed for adult patients who have experienced disease progression following endocrine therapy. Each tablet contains 150 mg of Alpelisib, which works by inhibiting the PI3K (phosphoinositide 3-kinase) pathway, a crucial signaling pathway involved in cell growth and survival. By blocking this pathway, Pivikto helps to slow down or stop the growth of cancer cells, making it an essential component of a comprehensive cancer treatment plan. Pivikto is typically prescribed in combination with other medications, such as Fulvestrant, to enhance its effectiveness. The drug is available in a pack of 28 tablets, providing a month’s supply for patients undergoing treatment.
Essential Drug Facts
| Dosage form | Oral Tablet |
|---|---|
| Chemical Class | Proline and derivatives |
| Habit Forming | No |
| Systemic Category | Oncology |
What are the Indication / Medical Uses of Pivikto 150MG Tablet (28’s)
Pivikto 150MG Tablet is indicated for the treatment of advanced or metastatic breast cancer in patients whose tumors are hormone receptor-positive and HER2-negative. It is specifically recommended for those who have previously received endocrine therapy and have shown disease progression. The use of Pivikto is part of a broader treatment strategy that may include other therapies, allowing for a more personalized approach to cancer care. This medication is crucial for patients who require additional options after standard treatments have failed, providing hope for improved outcomes in managing their condition.
How Does Pivikto 150MG Tablet (28’s) Benefit You?
The benefits of Pivikto 150MG Tablet for patients include its ability to target specific cancer pathways, which can lead to a reduction in tumor size and progression. By inhibiting the PI3K pathway, Pivikto can help to control the growth of cancer cells, potentially leading to longer survival rates and improved quality of life for patients with advanced breast cancer. Additionally, when used in combination with other therapies, Pivikto may enhance the overall effectiveness of treatment, offering patients a more robust approach to managing their disease.
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Pivikto 150MG Tablet (28’s) Action Mechanism
Pivikto 150MG Tablet works by selectively inhibiting the PI3K pathway, which is often activated in various cancers, including breast cancer. This pathway plays a significant role in cellular functions such as growth, proliferation, and survival. By blocking PI3K, Pivikto disrupts the signaling that promotes cancer cell growth and survival, leading to reduced tumor growth and potentially inducing cancer cell death. This targeted action makes Pivikto a valuable option in the treatment of hormone receptor-positive breast cancer, particularly in cases where traditional therapies have failed.
How should Pivikto 150MG Tablet (28’s) be used
To use Pivikto 150MG Tablet effectively, it is essential to follow the prescribed dosage and administration guidelines provided by a healthcare professional. Typically, the recommended dose is one tablet taken orally once daily, with or without food. It is crucial to take the medication at the same time each day to maintain consistent levels in the bloodstream. Patients should not crush or chew the tablet but swallow it whole with a glass of water. Adhering to the prescribed regimen is vital for maximizing the drug's effectiveness and minimizing potential side effects.
When is the best time to take Pivikto 150MG Tablet (28’s) ?
The best time to take Pivikto 150MG Tablet is once daily, preferably at the same time each day to establish a routine. Taking the medication consistently helps maintain stable drug levels in the body, which is essential for its effectiveness. Patients can choose to take it with or without food, but it is advisable to stick to the same method each day, whether that means taking it with meals or on an empty stomach. This consistency can help reduce the risk of gastrointestinal side effects and improve overall adherence to the treatment plan.
How does it affect me if I overdose?
In the event of an overdose of Pivikto 150MG Tablet, patients may experience severe side effects, which can include nausea, vomiting, diarrhea, and other gastrointestinal disturbances. Overdose can also lead to more serious complications, such as liver toxicity or severe allergic reactions. If an overdose is suspected, it is crucial to seek immediate medical attention to manage the situation effectively and mitigate any potential harm.
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How does it affect me if I miss a dose?
If a dose of Pivikto 150MG Tablet is missed, patients should take the missed dose as soon as they remember, unless it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Patients should not take two doses at once to make up for a missed dose, as this can increase the risk of side effects and complications. Consistent adherence to the medication schedule is important for optimal treatment outcomes.
Drug Adverse Reactions of Pivikto 150MG Tablet (28’s)
Pivikto 150MG Tablet may cause several side effects and adverse reactions, which can vary in severity among patients. Common side effects include diarrhea, nausea, vomiting, fatigue, and loss of appetite. Some patients may also experience skin rashes or elevated liver enzymes, indicating potential liver issues. It is essential for patients to report any unusual or severe side effects to their healthcare provider promptly, as adjustments to the treatment plan may be necessary to ensure safety and efficacy.
Pivikto 150MG Tablet (28’s) Tablet is contraindicated in following conditions
Pivikto 150MG Tablet is contraindicated in certain conditions, including patients with a known hypersensitivity to Alpelisib or any of the tablet's inactive ingredients. Additionally, it should not be used in patients with severe liver impairment or those who are pregnant, as the drug may pose risks to fetal development. It is crucial for healthcare providers to assess a patient's medical history and current health status before prescribing Pivikto to avoid potential complications.
Pivikto 150MG Tablet (28’s) Safety Warnings and Precautions
Alcohol may exacerbate some side effects of alpelisib, and patients are advised to limit alcohol consumption while on this medication to avoid potential interactions and increased side effects.
Patients with known allergies to alpelisib or any of its components should avoid its use, and those with a history of hypersensitivity should be monitored for allergic reactions.
Alpelisib has been shown to cause harm to the developing fetus in animal studies, and there is insufficient data on its safety in pregnant women, making it contraindicated during pregnancy.
The safety and efficacy of alpelisib have not been established in pediatric populations, and its use is not recommended in children.
It is not known whether alpelisib is excreted in human breast milk, and due to potential risks to a nursing infant, it is advised to use caution and consider the benefits versus risks when breastfeeding.
Alpelisib may cause side effects such as dizziness or fatigue, which could impair the ability to drive or operate machinery, so patients should assess their individual response before engaging in such activities.
Patients with renal impairment may require dose adjustments or careful monitoring due to the potential for altered drug clearance and increased risk of side effects.
Patients with a history of lung disease should be monitored, as alpelisib may cause respiratory side effects, and any new or worsening respiratory symptoms should be evaluated promptly.
Alpelisib is metabolized by the liver, and patients with hepatic impairment may experience increased drug exposure, necessitating dose adjustments and close monitoring.
Patients with pre-existing heart conditions should be monitored closely, as alpelisib may have cardiovascular effects that could exacerbate underlying issues.
Interactions between Pivikto 150MG Tablet (28’s)
Pivikto 150MG Tablet may interact with several other medications, potentially altering their effectiveness or increasing the risk of side effects. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions. Notable interactions may occur with other drugs that affect liver enzymes, as these can influence the metabolism of Alpelisib. Close monitoring and possible dosage adjustments may be necessary to ensure safe and effective treatment.
How to store and dispose of Pivikto 150MG Tablet (28’s)
To store Pivikto 150MG Tablet properly, keep it in a cool, dry place away from direct sunlight and moisture. The medication should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F). It is important to keep the tablets out of reach of children and pets to prevent accidental ingestion. When it comes to disposal, unused or expired medications should not be flushed down the toilet or poured down the drain. Instead, patients should follow local guidelines for medication disposal or consult their pharmacist for safe disposal options.
Here are a few quick tips for Pivikto 150MG Tablet (28’s)
Here are a few quick tips for using Pivikto 150MG Tablet effectively and safely: always take the medication as prescribed by your healthcare provider, and do not alter the dosage without consulting them first. Establish a routine by taking the tablet at the same time each day, and consider using a pill organizer to help keep track of doses. Stay hydrated and maintain a balanced diet to support your overall health during treatment. Regularly attend follow-up appointments for monitoring and discuss any side effects or concerns with your healthcare provider promptly.
Parameters that should be monitored Pivikto 150MG Tablet (28’s)
While using Pivikto 150MG Tablet, it is essential to monitor specific parameters to ensure safety and effectiveness. Regular blood tests should be conducted to assess liver function, as Alpelisib can impact liver enzymes. Additionally, monitoring for signs of gastrointestinal side effects, such as diarrhea or nausea, is crucial. Patients should also be vigilant for any allergic reactions or skin changes and report these to their healthcare provider immediately. Regular follow-ups will help in adjusting the treatment plan as needed.
Considerations related to diet Pivikto 150MG Tablet (28’s)
Dietary considerations while using Pivikto 150MG Tablet include maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins to support overall health. Patients should avoid excessive alcohol consumption, as it may exacerbate side effects and impact liver function. It is also advisable to stay hydrated, especially if experiencing gastrointestinal side effects like diarrhea. Consulting with a healthcare provider or nutritionist can help tailor dietary choices to support treatment and overall well-being.
Question and Answer (FAQ)
Q: What is Pivikto 150MG Tablet used for?
A: Pivikto 150MG Tablet is used to treat advanced or metastatic hormone receptor-positive, HER2-negative breast cancer in adults who have experienced disease progression after endocrine therapy.
Q: How does Pivikto work?
A: Pivikto works by inhibiting the PI3K pathway, which is involved in cancer cell growth and survival, thereby slowing down or stopping the growth of cancer cells.
Q: What should I do if I miss a dose of Pivikto?
A: If you miss a dose of Pivikto, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at once.
Q: What are the common side effects of Pivikto?
A: Common side effects of Pivikto include diarrhea, nausea, vomiting, fatigue, and loss of appetite. Some patients may also experience skin rashes.
Q: Can I take Pivikto with food?
A: Yes, Pivikto can be taken with or without food, but it is advisable to maintain the same method each day for consistency.
Q: Is Pivikto safe during pregnancy?
A: Pivikto is not safe during pregnancy and should be avoided due to potential risks to fetal development.
Q: How should Pivikto be stored?
A: Pivikto should be stored at room temperature, away from direct sunlight and moisture, and out of reach of children.
Q: What should I do if I overdose on Pivikto?
A: If you suspect an overdose of Pivikto, seek immediate medical attention to manage potential severe side effects.
Q: Can I drink alcohol while taking Pivikto?
A: Alcohol should be consumed with caution while taking Pivikto, as it may exacerbate side effects and impact liver function.
Q: Is Pivikto safe for children?
A: Pivikto is not recommended for use in children, as its safety and efficacy in pediatric populations have not been established.
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