Piciclib 100MG Capsule (21’s)
Piciclib 100MG Capsule (21’s) is a targeted oral medication primarily composed of Palbociclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). This drug is specifically designed for the treatment of certain types of breast cancer, particularly hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. By inhibiting CDK4 and CDK6, Piciclib helps to disrupt the cell cycle, thereby slowing down the proliferation of cancer cells. Each capsule contains 100 mg of Palbociclib, and it is typically prescribed in combination with aromatase inhibitors or other hormonal therapies to enhance its efficacy. The formulation is designed for easy oral administration, making it convenient for patients undergoing cancer treatment. As a part of a comprehensive cancer management plan, Piciclib plays a crucial role in improving patient outcomes and quality of life.
Essential Drug Facts
| Dosage form | Oral Tablet |
|---|---|
| Chemical Class | Pyridinylpiperazines |
| Habit Forming | No |
| Systemic Category | Oncology |
| Action Class | Cyclin-Dependent Kinase Inhibitor |
What are the Indication / Medical Uses of Piciclib 100MG Capsule (21’s)
The primary medical uses of Piciclib 100MG Capsule (21's) include the treatment of advanced or metastatic breast cancer in postmenopausal women. It is indicated for patients whose tumors express hormone receptors and do not overexpress HER2. The drug is often used in combination with letrozole or other hormonal therapies to enhance therapeutic effects. By targeting specific pathways involved in cancer cell growth, Piciclib helps to manage the disease effectively, prolonging progression-free survival and potentially improving overall survival rates in patients with HR+/HER2- breast cancer.
How Does Piciclib 100MG Capsule (21’s) Benefit You?
Piciclib 100MG Capsule (21's) offers significant benefits for patients diagnosed with HR+/HER2- breast cancer. By effectively inhibiting the CDK4/6 pathway, the drug slows down the growth and division of cancer cells, which can lead to a reduction in tumor size and a delay in disease progression. This targeted approach not only helps to manage symptoms associated with advanced breast cancer but also enhances the effectiveness of hormonal therapies when used in combination. Patients may experience improved quality of life and increased time without disease progression, making Piciclib a valuable option in the treatment landscape for breast cancer.
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Piciclib 100MG Capsule (21’s) Action Mechanism
The action mechanism of Piciclib 100MG Capsule (21's) involves the selective inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6), which are crucial for cell cycle progression. By blocking these kinases, Piciclib disrupts the transition from the G1 phase to the S phase of the cell cycle, effectively halting the proliferation of cancer cells. This mechanism is particularly effective in hormone receptor-positive breast cancer, where the growth of cancer cells is often driven by hormonal signals. By inhibiting CDK4/6, Piciclib not only slows down tumor growth but also enhances the effectiveness of concurrent hormonal therapies, leading to better treatment outcomes for patients.
How should Piciclib 100MG Capsule (21’s) be used
To use Piciclib 100MG Capsule (21's) effectively, it is essential to follow the prescribed dosage and administration guidelines provided by a healthcare professional. Typically, the recommended dosage is 125 mg taken orally once daily for 21 consecutive days, followed by a 7-day break, forming a 28-day treatment cycle. It is crucial to take the capsule at the same time each day, with or without food, to maintain consistent drug levels in the body. Patients should not crush or chew the capsules but swallow them whole with a glass of water. Adhering to the prescribed regimen is vital for maximizing the drug's therapeutic benefits.
When is the best time to take Piciclib 100MG Capsule (21’s) ?
The best time to take Piciclib 100MG Capsule (21's) is once daily, ideally at the same time each day to maintain a consistent schedule. Patients can take the medication with or without food, but it is advisable to choose a routine that aligns with their daily habits to enhance adherence. Consistency in timing helps to ensure optimal absorption and effectiveness of the drug, contributing to better management of the condition. If a patient has specific dietary preferences or restrictions, they should discuss these with their healthcare provider to ensure that they can take the medication safely and effectively.
How does it affect me if I overdose?
In the event of an overdose of Piciclib 100MG Capsule (21's), patients may experience severe side effects, which can include significant neutropenia (low white blood cell count), gastrointestinal disturbances, and other serious health complications. Overdose symptoms may vary, and immediate medical attention is crucial. If an overdose is suspected, it is essential to contact a healthcare professional or poison control center for guidance. Monitoring and supportive care may be necessary to manage any adverse effects resulting from the overdose.
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How does it affect me if I miss a dose?
If a dose of Piciclib 100MG Capsule (21's) is missed, patients should take the missed dose as soon as they remember on the same day. However, if it is almost time for the next scheduled dose, they should skip the missed dose and resume their regular dosing schedule. Patients should never take two doses at once to make up for a missed dose, as this can increase the risk of adverse effects. Consistent adherence to the dosing schedule is important for maintaining the drug's effectiveness in managing breast cancer.
Drug Adverse Reactions of Piciclib 100MG Capsule (21’s)
Piciclib 100MG Capsule (21's) may cause several adverse reactions, which can vary in severity among patients. Common side effects include neutropenia, fatigue, nausea, diarrhea, and mouth sores. Some patients may also experience hair loss, rash, or changes in liver function tests. While many side effects are manageable, it is important for patients to report any unusual or severe symptoms to their healthcare provider promptly. Regular monitoring and supportive care can help mitigate these adverse reactions and improve the overall treatment experience.
Piciclib 100MG Capsule (21’s) Tablet is contraindicated in following conditions
Piciclib 100MG Capsule (21's) is contraindicated in certain conditions, including patients with a known hypersensitivity to Palbociclib or any of its components. It should also be avoided in individuals with severe hepatic impairment, as the drug is primarily metabolized by the liver. Additionally, patients with a history of severe bone marrow suppression or those currently receiving strong CYP3A inhibitors should not use this medication, as these conditions can exacerbate the risk of serious side effects and reduce the drug's effectiveness.
Piciclib 100MG Capsule (21’s) Safety Warnings and Precautions
Alcohol may exacerbate side effects or interact with palbociclib, so it is advisable to limit or avoid alcohol consumption during treatment.
Patients with known allergies to palbociclib or any of its components should avoid its use and consult a healthcare provider for alternatives.
Palbociclib may cause harm to a developing fetus, and its use during pregnancy is contraindicated due to potential teratogenic effects.
The safety and efficacy of palbociclib in pediatric patients have not been established, making its use in children not recommended.
It is not known whether palbociclib is excreted in human breast milk, and its effects on a nursing infant are unknown, so caution is advised when considering its use while breastfeeding.
Palbociclib may cause fatigue or dizziness, which could impair the ability to drive or operate machinery, so caution is advised when engaging in such activities.
Patients with renal impairment may require dose adjustments or close monitoring, as palbociclib is primarily eliminated through the kidneys.
There is a potential risk of pulmonary complications, and patients with pre-existing lung conditions should be monitored for respiratory symptoms.
Patients with hepatic impairment may experience altered drug metabolism, necessitating careful monitoring and potential dose adjustments.
Palbociclib may cause cardiac issues, including changes in heart rhythm, so patients with pre-existing heart conditions should be monitored closely.
Interactions between Piciclib 100MG Capsule (21’s)
Piciclib 100MG Capsule (21's) may interact with several other medications, potentially altering their effectiveness or increasing the risk of adverse effects. Notably, strong CYP3A inhibitors, such as ketoconazole or ritonavir, can increase the concentration of Palbociclib in the body, leading to heightened side effects. Conversely, CYP3A inducers, such as rifampin, may decrease the effectiveness of Piciclib by reducing its levels. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions and ensure safe treatment.
How to store and dispose of Piciclib 100MG Capsule (21’s)
To store Piciclib 100MG Capsule (21's) properly, keep the medication in its original container at room temperature, away from moisture and direct sunlight. It is important to store the capsules out of reach of children and pets to prevent accidental ingestion. When it comes to disposal, patients should not flush the medication down the toilet or pour it down the drain. Instead, they should follow local regulations for medication disposal or consult their pharmacist for safe disposal options to minimize environmental impact.
Here are a few quick tips for Piciclib 100MG Capsule (21’s)
Here are a few quick tips for using Piciclib 100MG Capsule (21's) effectively and safely: always take the medication as prescribed by your healthcare provider, and do not adjust the dosage without consulting them first. Maintain a consistent daily schedule for taking the capsules to ensure optimal effectiveness. Keep track of any side effects you experience and report them to your healthcare provider promptly. Stay hydrated and maintain a balanced diet to support your overall health during treatment. Regularly attend follow-up appointments for blood tests and monitoring to ensure your safety while on this medication.
Parameters that should be monitored Piciclib 100MG Capsule (21’s)
While using Piciclib 100MG Capsule (21's), it is essential to monitor specific parameters to ensure the drug's safety and effectiveness. Regular blood tests should be conducted to check for neutropenia and other blood cell counts, as the medication can significantly affect bone marrow function. Liver function tests should also be performed periodically to monitor for any potential liver-related side effects. Patients should be vigilant for signs of infection, such as fever or chills, and report any unusual symptoms to their healthcare provider immediately.
Considerations related to diet Piciclib 100MG Capsule (21’s)
Dietary considerations while using Piciclib 100MG Capsule (21's) include maintaining a balanced diet rich in nutrients to support overall health and well-being. Patients should stay well-hydrated and consider avoiding excessive alcohol consumption, as it may exacerbate side effects. It is also advisable to discuss any specific dietary restrictions or preferences with a healthcare provider to ensure that the diet complements the treatment plan and does not interfere with the medication's effectiveness.
Question and Answer (FAQ)
Q: What is Piciclib 100MG Capsule used for?
A: Piciclib 100MG Capsule is used for the treatment of advanced or metastatic hormone receptor-positive, HER2-negative breast cancer.
Q: How does Piciclib work?
A: Piciclib works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which slows down the growth and division of cancer cells.
Q: What are the common side effects of Piciclib?
A: Common side effects include neutropenia, fatigue, nausea, diarrhea, and mouth sores.
Q: Can I take Piciclib with food?
A: Yes, you can take Piciclib with or without food, but it is best to take it at the same time each day.
Q: What should I do if I miss a dose of Piciclib?
A: If you miss a dose, take it as soon as you remember on the same day, but skip it if it's almost time for your next dose.
Q: Is Piciclib safe during pregnancy?
A: Caution is advised during pregnancy, as the effects on fetal development are not fully understood.
Q: Can I drink alcohol while taking Piciclib?
A: Caution is advised with alcohol consumption, as it may worsen side effects.
Q: How should I store Piciclib?
A: Store Piciclib at room temperature, away from moisture and direct sunlight, and out of reach of children.
Q: What should I do if I overdose on Piciclib?
A: If an overdose is suspected, seek immediate medical attention or contact a poison control center.
Q: Are there any dietary restrictions while taking Piciclib?
A: While there are no specific dietary restrictions, maintaining a balanced diet and staying hydrated is recommended.
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