Pazib 400MG Tablet (30’s)

Pazib 400MG Tablet, containing the active ingredient Pazopanib at a dosage of 400mg, is a targeted therapy primarily used in the treatment of advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma. This medication works by inhibiting multiple tyrosine kinases, which are enzymes involved in the signaling pathways that promote tumor growth and angiogenesis (the formation of new blood vessels that supply tumors). By blocking these pathways, Pazib helps to slow down or stop the growth of cancer cells. The tablet is typically prescribed for patients who have not responded to other treatments or for whom other therapies are not suitable. It is essential for patients to follow their healthcare provider’s instructions regarding the use of this medication to achieve optimal results. Pazib is available in a pack of 30 tablets, making it convenient for patients to manage their treatment regimen.

Essential Drug Facts

Dosage form	Oral Tablet
Chemical Class	Alkyldiarylamines Derivative
Habit Forming	No
Systemic Category	Oncology
Action Class	Tyrosine kinase inhibitors

What are the Indication / Medical Uses of Pazib 400MG Tablet (30’s)

Pazib 400MG Tablet is indicated for the treatment of advanced renal cell carcinoma and soft tissue sarcoma. It is particularly beneficial for patients who have previously undergone other forms of therapy without success. The drug is designed to target specific pathways that are crucial for the growth and spread of cancer cells, making it a vital option in the oncological treatment landscape. By focusing on these pathways, Pazib can help improve patient outcomes and prolong survival in those battling these aggressive forms of cancer.

How Does Pazib 400MG Tablet (30’s) Benefit You?

The benefits of Pazib 400MG Tablet for patients include its ability to effectively slow down the progression of advanced kidney cancer and soft tissue sarcoma. By targeting specific molecular pathways involved in tumor growth, Pazib can help reduce tumor size and improve overall survival rates. Additionally, patients may experience a better quality of life as the drug works to manage symptoms associated with cancer. Regular monitoring and adherence to the prescribed treatment plan can further enhance the therapeutic benefits of Pazib, making it a crucial component of cancer management for eligible patients.

Pazib 400MG Tablet (30’s) Action Mechanism

Pazib 400MG Tablet exerts its therapeutic effects through a mechanism of action that involves the inhibition of multiple tyrosine kinases, including vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR). These receptors play a significant role in tumor cell proliferation and angiogenesis. By blocking these receptors, Pazopanib disrupts the signaling pathways that promote cancer cell growth and the formation of new blood vessels, effectively starving the tumor of the nutrients and oxygen it needs to grow. This targeted approach not only helps to shrink existing tumors but also prevents the formation of new ones, contributing to improved patient outcomes.

How should Pazib 400MG Tablet (30’s) be used

To use Pazib 400MG Tablet effectively, it is essential to follow the dosage instructions provided by your healthcare provider. Typically, the recommended dosage is one tablet taken once daily, with or without food. It is crucial to take the tablet at the same time each day to maintain consistent levels of the medication in your system. Patients should swallow the tablet whole with a glass of water and avoid crushing or chewing it. If a dose is missed, it should be taken as soon as remembered, unless it is close to the time for the next dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. Patients should not take two doses at once to make up for a missed dose.

When is the best time to take Pazib 400MG Tablet (30’s) ?

The best time to take Pazib 400MG Tablet is once daily, ideally at the same time each day to maintain a consistent routine. Whether taken with or without food, it is important to choose a time that fits well into the patient's daily schedule. This consistency helps ensure that the medication is effective and minimizes the risk of missed doses. Patients should consult their healthcare provider if they have any questions about the timing of their medication.

How does it affect me if I overdose?

In the event of an overdose of Pazib 400MG Tablet, patients may experience severe side effects, which can include symptoms such as nausea, vomiting, diarrhea, and liver dysfunction. Overdosing can lead to serious health complications, and immediate medical attention is necessary. If an overdose is suspected, it is crucial to contact a healthcare professional or poison control center right away for guidance on the appropriate steps to take.

How does it affect me if I miss a dose?

If a dose of Pazib 400MG Tablet is missed, patients should take the missed dose as soon as they remember, unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped, and the patient should continue with their regular dosing schedule. It is important not to double up on doses to compensate for a missed one, as this can increase the risk of side effects and complications.

Drug Adverse Reactions of Pazib 400MG Tablet (30’s)

Pazib 400MG Tablet may cause a range of side effects and adverse reactions, which can vary in severity among patients. Common side effects include diarrhea, nausea, vomiting, fatigue, and changes in liver function tests. Some patients may also experience high blood pressure, skin rashes, and decreased appetite. Serious side effects, although less common, can include liver toxicity, heart problems, and severe allergic reactions. Patients should report any unusual or severe symptoms to their healthcare provider promptly to ensure appropriate management.

Pazib 400MG Tablet (30’s) Tablet is contraindicated in following conditions

Pazib 400MG Tablet is contraindicated in certain conditions, including severe liver impairment, as the drug is metabolized in the liver and can exacerbate liver dysfunction. Additionally, it should not be used in patients with a known hypersensitivity to Pazopanib or any of its components. Caution is also advised in patients with a history of heart disease or uncontrolled hypertension, as Pazib can affect cardiovascular health. It is essential for patients to disclose their complete medical history to their healthcare provider before starting treatment with Pazib.

Pazib 400MG Tablet (30’s) Safety Warnings and Precautions

Alcohol:CAUTION

Alcohol may exacerbate side effects such as dizziness and liver toxicity, so it is advisable to limit or avoid alcohol consumption while on this medication.

Allergy:CAUTION

Patients with a known allergy to Pazopanib or any of its components should avoid its use, and any signs of an allergic reaction should be reported immediately.

Pregnancy:UNSAFE

Pazopanib may cause fetal harm and is contraindicated during pregnancy due to potential risks to the developing fetus.

Children:CAUTION

The safety and efficacy of Pazopanib in pediatric patients have not been established, and its use should be approached with caution.

Lactation:UNSAFE

It is not known whether Pazopanib is excreted in human milk, and due to potential risks to a nursing infant, breastfeeding is not recommended while taking this medication.

Drive:CAUTION

Pazopanib may cause dizziness or fatigue, which can impair the ability to drive or operate machinery, so caution is advised when engaging in such activities.

Kidney:CAUTION

Patients with renal impairment may require dose adjustments, and careful monitoring is advised due to the potential for increased side effects.

Lungs:CAUTION

There is a risk of pulmonary toxicity, including interstitial lung disease, and patients should be monitored for respiratory symptoms during treatment.

Liver:CAUTION

Pazopanib is primarily metabolized by the liver, and patients with hepatic impairment may experience increased drug exposure, necessitating dose adjustments and close monitoring.

Heart:CAUTION

Pazopanib can cause cardiovascular side effects, including hypertension and heart failure, so patients with pre-existing heart conditions should be monitored closely.

Interactions between Pazib 400MG Tablet (30’s)

Pazib 400MG Tablet may interact with various other medications, potentially altering their effectiveness or increasing the risk of side effects. Notable interactions can occur with drugs that affect liver enzymes, particularly those that induce or inhibit cytochrome P450 enzymes. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions and ensure safe and effective treatment.

How to store and dispose of Pazib 400MG Tablet (30’s)

To store Pazib 400MG Tablet properly, keep it in a cool, dry place away from direct sunlight and moisture. The medication should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F). It is important to keep the tablets out of reach of children and pets. When it comes to disposal, unused or expired medications should not be flushed down the toilet or poured down the drain. Instead, patients should follow local guidelines for medication disposal or consult their pharmacist for safe disposal options.

Here are a few quick tips for Pazib 400MG Tablet (30’s)

Here are a few quick tips for using Pazib 400MG Tablet effectively and safely: Always take the medication as prescribed by your healthcare provider, and do not adjust the dosage without consulting them first. Maintain a consistent daily routine by taking the tablet at the same time each day. Monitor your blood pressure regularly, as Pazib can affect cardiovascular health. Stay hydrated and maintain a balanced diet to support your overall health during treatment. Report any unusual symptoms or side effects to your healthcare provider promptly, and attend all scheduled follow-up appointments for monitoring and assessment.

Parameters that should be monitored Pazib 400MG Tablet (30’s)

While using Pazib 400MG Tablet, it is essential to monitor specific parameters to ensure safe and effective treatment. Regular blood tests should be conducted to assess liver function, kidney function, and blood cell counts. Patients should also have their blood pressure monitored frequently, as hypertension is a common side effect of the medication. Any significant changes in these parameters may require adjustments to the treatment plan or additional interventions.

Considerations related to diet Pazib 400MG Tablet (30’s)

Dietary considerations while using Pazib 400MG Tablet include maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Patients should avoid excessive consumption of alcohol, as it can exacerbate side effects and liver toxicity. It is also advisable to limit high-fat meals, as they may affect the absorption of the medication. Patients should consult their healthcare provider or a registered dietitian for personalized dietary recommendations during treatment.