Piciclib 125MG Capsule (21’s)
Piciclib 125MG Capsule (21’s) is a targeted oral medication primarily used in the treatment of certain types of breast cancer, particularly hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. The active ingredient in this formulation is Palbociclib, which is a cyclin-dependent kinase (CDK) 4/6 inhibitor. This drug works by interfering with the cancer cell cycle, thereby inhibiting the proliferation of cancer cells. Each capsule contains 125 mg of Palbociclib, and the packaging typically includes 21 capsules, which is designed to facilitate a standard treatment regimen. Piciclib is often prescribed in combination with aromatase inhibitors or other hormonal therapies to enhance its efficacy. The drug is well-regarded for its ability to extend progression-free survival in patients, making it a vital option in the oncology therapeutic arsenal.
Essential Drug Facts
| Dosage form | Oral Tablet |
|---|---|
| Chemical Class | Pyridinylpiperazines |
| Habit Forming | No |
| Systemic Category | Oncology |
| Action Class | Cyclin-Dependent Kinase Inhibitor |
What are the Indication / Medical Uses of Piciclib 125MG Capsule (21’s)
The primary medical uses of Piciclib 125MG Capsule (21's) include the treatment of advanced or metastatic breast cancer in postmenopausal women, particularly those with HR+/HER2- tumors. It is indicated for use in combination with letrozole or other hormonal therapies to improve treatment outcomes. The drug is specifically designed for patients who have not received prior systemic therapy for their advanced disease, making it a crucial option for managing breast cancer effectively. By targeting specific pathways involved in cancer cell growth, Piciclib helps to slow down the progression of the disease and improve the quality of life for patients.
How Does Piciclib 125MG Capsule (21’s) Benefit You?
Piciclib 125MG Capsule (21's) offers significant benefits for patients diagnosed with HR+/HER2- breast cancer. By inhibiting the CDK 4/6 pathway, the drug effectively slows down the growth and division of cancer cells, which can lead to a longer progression-free survival period. This means that patients may experience a delay in the advancement of their cancer, allowing for a better quality of life during treatment. Additionally, when used in combination with hormonal therapies, Piciclib can enhance the overall effectiveness of the treatment, providing a more comprehensive approach to managing breast cancer. The drug is generally well-tolerated, and many patients can continue their daily activities while undergoing treatment.
.svg)
Piciclib 125MG Capsule (21’s) Action Mechanism
Piciclib 125MG Capsule (21's) exerts its therapeutic effects through a specific mechanism of action that targets the cell cycle regulation in cancer cells. By inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), Piciclib disrupts the phosphorylation of the retinoblastoma protein (Rb), which is crucial for cell cycle progression. This inhibition prevents the transition from the G1 phase to the S phase of the cell cycle, effectively halting the proliferation of cancer cells. As a result, the drug not only slows down tumor growth but also enhances the effectiveness of concurrent hormonal therapies, making it a vital component in the treatment of HR+/HER2- breast cancer.
How should Piciclib 125MG Capsule (21’s) be used
For optimal results, Piciclib 125MG Capsule (21's) should be taken as prescribed by a healthcare professional. The typical dosage is 125 mg taken orally once daily for 21 consecutive days, followed by a 7-day break, which constitutes a complete treatment cycle of 28 days. It is essential to take the capsule at the same time each day to maintain consistent drug levels in the body. Patients should swallow the capsule whole with water and avoid crushing or chewing it. It is also advisable to take the medication with food to minimize gastrointestinal side effects, although it can be taken without food if necessary.
When is the best time to take Piciclib 125MG Capsule (21’s) ?
The best time to take Piciclib 125MG Capsule (21's) is in the morning, ideally with breakfast. Taking the medication at the same time each day helps establish a routine, which can improve adherence to the treatment regimen. Consistency is key in maximizing the drug's effectiveness, and taking it with food can help reduce the risk of gastrointestinal discomfort. Patients should follow their healthcare provider's instructions regarding the timing and dosage to ensure optimal therapeutic outcomes.
How does it affect me if I overdose?
In the event of an overdose of Piciclib 125MG Capsule (21's), patients may experience severe side effects, including increased toxicity and exacerbation of adverse reactions. Symptoms of overdose can include severe neutropenia (low white blood cell count), which increases the risk of infections, as well as gastrointestinal symptoms such as nausea, vomiting, and diarrhea. If an overdose is suspected, it is crucial to seek immediate medical attention to manage the situation effectively and mitigate potential complications.
.svg)
How does it affect me if I miss a dose?
If a dose of Piciclib 125MG Capsule (21's) is missed, patients should take the missed dose as soon as they remember on the same day. However, if it is almost time for the next scheduled dose, they should skip the missed dose and continue with their regular dosing schedule. Patients should not take two doses at once to make up for a missed dose, as this can increase the risk of side effects and toxicity. Consistent communication with healthcare providers is essential to manage any missed doses effectively.
Drug Adverse Reactions of Piciclib 125MG Capsule (21’s)
Piciclib 125MG Capsule (21's) may cause several adverse reactions, which can vary in severity among patients. Common side effects include neutropenia, fatigue, nausea, diarrhea, and mouth sores. Some patients may also experience hair loss, rash, or changes in liver function tests. While many side effects are manageable, it is important for patients to report any severe or persistent symptoms to their healthcare provider promptly. Regular monitoring and supportive care can help mitigate these adverse effects and improve the overall treatment experience.
Piciclib 125MG Capsule (21’s) Tablet is contraindicated in following conditions
Piciclib 125MG Capsule (21's) is contraindicated in certain conditions, including patients with a known hypersensitivity to Palbociclib or any of the capsule's inactive ingredients. Additionally, it should not be used in patients with severe hepatic impairment, as the drug is primarily metabolized by the liver, and impaired liver function can lead to increased drug levels and toxicity. Patients with a history of severe bone marrow suppression or those currently receiving strong CYP3A inhibitors should also avoid using this medication, as these conditions can exacerbate the risk of adverse effects.
Piciclib 125MG Capsule (21’s) Safety Warnings and Precautions
Alcohol may exacerbate side effects associated with palbociclib, and patients are advised to limit alcohol consumption while on this medication.
Patients with a known allergy to palbociclib or any of its components should avoid its use, and those with a history of hypersensitivity should be monitored for allergic reactions.
Palbociclib has been shown to cause harm to the developing fetus in animal studies, and its safety in pregnant women has not been established, making it contraindicated during pregnancy.
The safety and efficacy of palbociclib in pediatric patients have not been established, and it is not approved for use in children.
It is not known whether palbociclib is excreted in human breast milk, and due to potential risks to a nursing infant, breastfeeding is generally not recommended while taking this medication.
Palbociclib may cause fatigue or dizziness, which can impair the ability to drive or operate machinery, so patients should exercise caution when engaging in these activities.
Patients with renal impairment may require dose adjustments, and careful monitoring is advised due to the potential for altered drug clearance.
There is a potential risk of pulmonary toxicity with palbociclib, and patients with pre-existing lung conditions should be monitored for respiratory symptoms.
Patients with hepatic impairment may experience increased exposure to palbociclib, necessitating dose adjustments and close monitoring of liver function.
Palbociclib may cause cardiac issues, including changes in heart rhythm, and patients with pre-existing heart conditions should be monitored closely.
Interactions between Piciclib 125MG Capsule (21’s)
Piciclib 125MG Capsule (21's) may interact with several other medications, which can affect its efficacy and safety. Notably, strong CYP3A inhibitors, such as ketoconazole and ritonavir, can increase the levels of Palbociclib in the body, leading to a higher risk of adverse effects. Conversely, CYP3A inducers, like rifampin and St. John's Wort, may decrease the effectiveness of Piciclib by lowering its concentration. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions and ensure safe treatment.
How to store and dispose of Piciclib 125MG Capsule (21’s)
To store Piciclib 125MG Capsule (21's) properly, keep the medication in its original container at room temperature, away from moisture and heat. It is essential to store the capsules out of reach of children and pets to prevent accidental ingestion. When it comes to disposal, patients should not flush the medication down the toilet or pour it down the drain. Instead, unused or expired capsules should be returned to a pharmacy or disposed of in accordance with local regulations for hazardous waste to ensure environmental safety.
Here are a few quick tips for Piciclib 125MG Capsule (21’s)
Here are a few quick tips for using Piciclib 125MG Capsule (21's) effectively and safely: Always take the medication as prescribed by your healthcare provider, and do not adjust the dosage without consulting them. Establish a routine by taking the capsule at the same time each day, preferably with food, to minimize gastrointestinal side effects. Keep track of your treatment cycles and any missed doses, and communicate regularly with your healthcare provider about any side effects or concerns. Regular blood tests are essential to monitor your blood cell counts and liver function during treatment. Lastly, maintain a healthy lifestyle, including a balanced diet and adequate hydration, to support your overall well-being while on this medication.
Parameters that should be monitored Piciclib 125MG Capsule (21’s)
While using Piciclib 125MG Capsule (21's), several parameters should be monitored to ensure patient safety and treatment efficacy. Regular blood tests are crucial to assess complete blood counts, particularly for neutrophil levels, as the drug can cause neutropenia. Liver function tests should also be conducted periodically to monitor for any signs of hepatic impairment. Additionally, patients should be monitored for any signs of infection, gastrointestinal symptoms, or other adverse reactions. Close communication with healthcare providers is essential to address any concerns and adjust treatment as necessary.
Considerations related to diet Piciclib 125MG Capsule (21’s)
Dietary considerations while using Piciclib 125MG Capsule (21's) include maintaining a balanced diet rich in nutrients to support overall health during treatment. Patients should aim to consume a variety of fruits, vegetables, whole grains, and lean proteins. It is advisable to avoid excessive alcohol consumption, as it may exacerbate side effects. Additionally, patients should stay well-hydrated and consider discussing any specific dietary restrictions or recommendations with their healthcare provider to optimize their treatment experience.
Question and Answer (FAQ)
Q: What is Piciclib 125MG Capsule used for?
A: Piciclib 125MG Capsule is used to treat advanced or metastatic breast cancer in postmenopausal women, particularly those with HR+/HER2- tumors.
Q: How should I take Piciclib 125MG Capsule?
A: Take one capsule daily for 21 days, followed by a 7-day break, preferably with food and at the same time each day.
Q: What are the common side effects of Piciclib?
A: Common side effects include neutropenia, fatigue, nausea, diarrhea, and mouth sores.
Q: Can I take Piciclib if I am pregnant?
A: Caution is advised, as the effects of Piciclib on fetal development are not fully understood.
Q: Is it safe to breastfeed while taking Piciclib?
A: Caution is advised, as it is not known if Piciclib is excreted in breast milk.
Q: What should I do if I miss a dose of Piciclib?
A: If you miss a dose, take it as soon as you remember on the same day, but skip it if it's almost time for your next dose.
Q: What happens if I overdose on Piciclib?
A: An overdose may lead to severe side effects, including increased toxicity and exacerbation of adverse reactions.
Q: Are there any drug interactions with Piciclib?
A: Yes, strong CYP3A inhibitors and inducers can affect the levels and effectiveness of Piciclib.
Q: How should I store Piciclib 125MG Capsule?
A: Store the capsules at room temperature, away from moisture and heat, and out of reach of children.
Q: What dietary considerations should I keep in mind while taking Piciclib?
A: Maintain a balanced diet, stay hydrated, and limit alcohol consumption to support overall health during treatment.
Reviews
There are no reviews yet.