Actorise 60MCG Injection (0.3ml)
Actorise 60MCG Injection is a medication that contains Darbepoetin alfa, a synthetic form of erythropoietin, a hormone that your body naturally produces to stimulate the production of red blood cells. With significantly enhanced sialic acid content, Darbepoetin alfa has a longer circulation half-life, permitting less frequent dosing than traditional erythropoietin. This medication is used to treat anemia resulting from chronic kidney disease or cancer treatments, or to combat anemia in patients undergoing surgeries involving significant blood loss. It is a versatile and valuable medication, offering substantial relief from the fatigue and decreased energy levels associated with anemia.
Essential Drug Facts
| Dosage form | SC(Subcutaneous) Injection |
|---|---|
| Chemical Class | Amino acids, Peptides analogues |
| Habit Forming | No |
| Systemic Category | Cardiovascular & Hematopoietic system |
| Action Class | Erythropoiesis-stimulating agent (ESA) |
What are the Indication / Medical Uses of Actorise 60MCG Injection (0.3ml)
Actorise 60MCG Injection is primarily utilized for the management of anemia associated with CKD (chronic kidney disease) in both adults and children. It is also indicated for the management of anemia in adults who are undergoing chemotherapy for non-myeloid malignancies and whose anemia can not be managed by iron supplementation. Additionally, it is employed in anemia prevention for patients undergoing certain types of surgeries.
How Does Actorise 60MCG Injection (0.3ml) Benefit You?
The use of Actorise 60MCG Injection is beneficial for work against the symptoms of anemia, which include fatigue, weakness, shortness of breath, and pallor. By stimulating red blood cell production, it aids in the return of more normal energy levels and helps patients feel better overall. Furthermore, Actorise reduces the reliance on frequent blood transfusion, thus limiting potential blood-borne infections or transfusion-related adverse reactions.
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Actorise 60MCG Injection (0.3ml) Action Mechanism
Actorise 60MCG Injection functions by effectively mimicking the natural erythropoietin in the body. Darbepoetin alfa, the main constituent, binds with the erythropoietin receptor on the red blood cell precursors in the bone marrow, stimulating them to produce more mature red blood cells (RBC). These cells are then released into the bloodstream, improving the oxygen-carrying capacity and resolving the symptoms of anemia.
How should Actorise 60MCG Injection (0.3ml) be used
Actorise 60MCG Injection should only be given by healthcare professionals in a clinical setting. It can be administered either subcutaneously (under the skin) or via intravenous infusion. The dosage depends on the patient's specific needs, including the severity of their anemia, their body weight, and how they've responded to past treatments.
When is the best time to take Actorise 60MCG Injection (0.3ml) ?
The optimal time to administer Actorise 60MCG Injection varies and is typically determined by the prescribing healthcare professional based on the patient's specific treatment course, the severity of their anemia, and how they have previously responded to the medication.
How does it affect me if I overdose?
An overdose of Actorise 60MCG Injection can lead to an unsafe increase in red blood cell production, which can lead to conditions like thrombosis, stroke, heart attack or other cardiovascular events. Symptoms may include shortness of breath, chest pain, dizziness, or weakness on one side of the body. Immediate medical attention is necessary in these cases.
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How does it affect me if I miss a dose?
Missing a dose of Actorise 60MCG Injection can cause a disruption in red blood cell production, leading to a return of anemia symptoms. Patients are encouraged to adhere to their prescribed regimen to maintain optimal results.
Drug Adverse Reactions of Actorise 60MCG Injection (0.3ml)
Adverse reactions of Actorise 60MCG Injection may include high blood pressure, headache, joint pain, dizziness, and irritation at the injection site. Less common but severe reactions may include allergic reactions, blood clots, stroke, and seizures. Immediate medical attention is required for these serious side effects.
Actorise 60MCG Injection (0.3ml) Tablet is contraindicated in following conditions
Actorise 60MCG Injection is contraindicated in patients with hypersensitivity to darbepoetin alfa or any of its components. Also, it is not suitable for patients with uncontrolled hypertension or those diagnosed with pure red cell aplasia (a rare disorder where the bone marrow fails to produce red blood cells) following prior treatment with any erythropoietin product.
Actorise 60MCG Injection (0.3ml) Safety Warnings and Precautions
While no specific contraindications exist, patients are generally advised to limit alcohol intake as part of general health advice.
Those with known hypersensitivity to the drug's components should avoid its use.
It is recommended to use Actorise during pregnancy only if the benefits offered outweigh the risks posed to the fetus.
Though effective in children for treating anemia related to CKD, it requires careful dosing and monitoring.
Not enough data exist about the excretion of Actorise in human breast milk, so it should be used cautiously in breastfeeding mothers.
Actorise is not known to impair driving abilities. However, if patients experience side effects like dizziness, they should avoid driving.
Patients with chronic kidney disease should have regular monitoring during treatment.
No significant pulmonary complications are associated with Actorise.
As liver impairment could alter the drug's metabolism, patients with liver dysfunctions should be monitored closely.
Increased risks of cardiovascular events necessitate heightened caution in patients with heart conditions.
Interactions between Actorise 60MCG Injection (0.3ml)
Several medications might interfere with the activity of Darbepoetin alfa. It's essential to inform the healthcare provider about all current medications, including over-the-counter drugs, prescriptions, vitamins, and herbal supplements.
How to store and dispose of Actorise 60MCG Injection (0.3ml)
Actorise 60MCG should be stored in a refrigerator at a temperature between 2°C - 8°C, and kept in the original packaging to protect from light. Freezing should be avoided. Waste disposal should follow the local guidelines for biohazardous waste.
Here are a few quick tips for Actorise 60MCG Injection (0.3ml)
It's essential to have transparent and open communication with your healthcare provider when thinking about getting Actorise 60MCG Injection. Make sure to discuss your complete medical history and any other medications you're taking to ensure your overall health is taken into account. Strict adherence to the prescribed dose and schedule is key, and regular monitoring of hemoglobin levels and blood pressure is a must. It's also critical to promptly report any adverse reactions or side effects to your doctor.
Parameters that should be monitored Actorise 60MCG Injection (0.3ml)
It is essential to monitor regular hemoglobin levels, complete blood counts, blood pressure, iron status, and renal function (in CKD patients) regularly. Monitoring signs of cardiovascular health is equally important.
Considerations related to diet Actorise 60MCG Injection (0.3ml)
A balanced diet enriched with iron, vitamin B12, and folic acid can help red blood cell production and could enhance the therapy effects of Actorise.
Question and Answer (FAQ)
Q: What is Actorise 60MCG Injection used for?
A: It is used for treating anemia associated with chronic kidney disease and in cancer patients undergoing chemotherapy.
Q: When should Actorise 60MCG Injection be taken?
A: The optimal time for administration is determined by the physician after considering various patient-specific factors.
Q: What happens when I miss an Actorise dose?
A: Missing a dose may result in a return of anemia symptoms; hence, it is essential to adhere to the prescribed regimen.
Q: Can Actorise 60MCG Injection be taken during pregnancy?
A: Caution is advised and the drug should only be taken if the potential benefit outweighs the potential risk to the fetus.
Q: Is Actorise 60MCG Injection safe for breastfeeding mothers?
A: Due to the lack of data regarding excretion in human milk, Actorise should be used with caution in lactating women.
Q: What are the side effects of Actorise 60MCG Injection?
A: Common side effects include hypertension, headaches, swelling at the injection site, and joint pain.
Q: Can Actorise 60MCG Injection cause allergic reactions?
A: Yes, in rare cases, Actorise can cause allergic reactions in people who are hypersensitive to its components.
Q: Can Actorise 60MCG Injection cause an overdose?
A: Yes, an overdose can lead to the excessive production of red blood cells which can potentially be harmful.
Q: Is Actorise 60MCG Injection safe for children?
A: Yes, it can be used to manage anemia in children with CKD, but careful dosing and monitoring are required.
Q: Is it safe to drive after taking Actorise 60MCG Injection?
A: Actorise doesn't typically interfere with the ability to drive, but patients experiencing side effects like dizziness should avoid driving.
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